Numerical simulation and post processing of tumor microvasculature / 医用生物力学

ABSTRACT

Objective In order to provide a more realistic microvasculature model for the study on tumor hemodynamics and drug delivery, a simulated tumor microvascular network was developed by the technique of numerical simulation and post processing. Method We constructed a tumor microvascular model with host arteriole venule system, in which the variation in vascular branching and dimensions was taken into account. A sensitivity analysis was made for the parameters of the model to evaluate the adjustability of simulated results. The connectivity of the vascular network was tested to ensure the integrity of the network. The vascular network was smoothed afterwards to reduce flow resistance resulting from numerical networks. Results The simulated results are consistent with the characteristics of real tumor microvasculature, which show intact circulation, local adjustability, high network connectivity and smooth degree. Conclusions This study provid a numerical microvasculature model for the research on tumor hemodynamics, drug delivery and vascular targeted therapy.