Progress of mechanotransduction in differentiation of bone marrow mesenchymal stem cells mediated by cellular mechanosensor and TNTs / 医用生物力学

ABSTRACT

With the regulation of mechanical microenvironment being realized as an important role playing in the differentiation of bone marrow mesenchymal stem cells (BMSCs), the systematic researches on stem cells are gradually deepened into the extended cellular biomechanical field, which lead to a hot research focus on cellular biomechanical properties, basic mechanical structure units and network-like mechanical architecture among cells. In this paper the analysis on mechanical properties of BMSCs and mechanical molecular basic research on integrins and cadherins are reviewed, and the main frame of network like mechanical regulation is speculated and constructed, combined with the internal bony structure and mechanical geometric properties of the tunneling nanotubes (TNTs). The possibility of synergistic effect among the above important mechanical structures in the network-like mechanical microenvironment is also investigated.