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Research progress in neurotoxicity of HIV-1 viral protein R / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology ; (6): 323-326, 2019.
Artigo em Chinês | WPRIM | ID: wpr-804836
ABSTRACT
Viral Protein R (Vpr) is an accessory protein of HIV-1 that increases the infectivity of HIV-1, activates latent viruses, and acts with other accessory proteins. A number of studies have demonstrated the important role of Vpr in the pathogenesis of HIV-1 related neurological diseases. Vpr can disrupt the integrity of the blood-brain barrier, induce neuronal apoptosis, and may be an important causative agent of AIDS dementia syndrome. However, the exact mechanism is still unknown. This review elaborates the neurotoxic effects of HIV-1 Vpr.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Experimental and Clinical Virology Ano de publicação: 2019 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Experimental and Clinical Virology Ano de publicação: 2019 Tipo de documento: Artigo