P0 protein promotes the expression of INF-γ and IL-10 in peripheral blood of n-hexane neuropathy patients / 中华劳动卫生职业病杂志

ABSTRACT

Objective@#To study the changes of monocyte cytokines in peripheral blood of n-hexane neuropathy patients induced by P0 protein, and to explore the role of autoimmunity in n-hexane neuropathy patients.@*Methods@#In May 2018, 5 patients with peripheral neuropathy diagnosed as n-hexane poisoning were selected as case group in Shenzhen Prevention and Treatment Center for Occupational Disease in 2017. 6 workers exposure to n-hexane and 6 workers without n-hexane exposure were selected as contact group and control group. Peripheral blood mononuclear cells(PBMC) were isolated from venous blood.@*Results@#The number of spots produced by INF-γ and IL-10 increased after stimulation with P0 protein in case group, and the positive rate was significantly higher than control group and the contact group.@*Conclusion@#Autoimmunity induced by P0 protein may be involved in the occurrence of myelin sheath damage in n-hexane neuropathy patients.