Clinical characteristics of ulcerative colitis with cytomegalovirus infection / 中华实验和临床病毒学杂志

ABSTRACT

Objective@#To investigate the clinical characteristics and outcomes of ulcerative colitis (UC) with cytomegalovirus (CMV) infection.@*Methods@#The related data of 300 patients with UC who were treated in the department of gastroenterology of the First Affiliated Hospital of Xiamen University from January 2013 to October 2017 were analyzed retrospectively. Eighty cases with CMV infection were included into the observation group while 220 cases without CMV infection were enrolled into the control group. The disease characteristics, clinical features, treatment and outcomes were compared between the two groups.@*Results@#For disease characteristics, course of disease in observation group was significantly shorter than that in the control group (t=18.498, P<0.05). The previous application rates of glucocorticoid and immunosuppressant in the observation group were significantly higher than those in the control group (χ2=31.241, 10.381, P<0.05). The incidence rates of glucocorticoid dependence and glucocorticoid resistance in the observation group were significantly higher than those in the control group (χ2=17.513, 64.927, P<0.05). For clinical characteristics, the incidence rates of fever, abdominal pain and weight loss in the observation group were significantly higher than those in the control group (χ2=25.112, 20.633, 13.000, P<0.05). Colonoscopy showed that the ulcer rate in observation group was significantly higher than that in the control group (χ2=15.496, P<0.05). For outcomes, the improvement rate of the observation group was significantly lower than that of the control group (55.00% vs. 79.55%) (χ2=17.933, P<0.05).@*Conclusions@#The clinical symptoms of patients with UC and CMV infection are more obvious, the disease was more serious, the ulcer rate is higher and the clinical outcomes were worse than those of uninfected patients.