Ganoderma Lucidum Protects Rat Brain Tissue Against Trauma-Induced Oxidative Stress / 대한신경손상학회지
Korean Journal of Neurotrauma
;
: 76-84, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-80644
ABSTRACT
OBJECTIVE:
Traumatic brain injury causes tissue damage, breakdown of cerebral blood flow and metabolic regulation. This study aims to investigate the protective influence of antioxidant Ganoderma lucidum (G. lucidum) polysaccharides (GLPs) on brain injury in brain-traumatized rats.METHODS:
Sprague-Dawley conducted a head-traumatized method on rats by dropping off 300 g weight from 1 m height. Groups were categorized as control, G. lucidum, trauma, trauma+ G. lucidum (20 mL/kg per day via gastric gavage). Brain tissues were dissected from anesthetized rats 7 days after injury. For biochemical analysis, malondialdehyde, glutathione and myeloperoxidase values were measured.RESULTS:
In histopathological examination, neuronal damage in brain cortex and changes in blood brain barrier were observed. In the analysis of immunohistochemical and western blot, p38 mitogen-activated protein kinase, vascular endothelial growth factor and cluster of differentiation 68 expression levels were shown. These analyzes demonstrated the beneficial effects of GLPs on brain injury.CONCLUSION:
We propose that GLPs treatment after brain injury could be an alternative treatment to decraseing inflammation and edema, preventing neuronal and glial cells degeneration if given in appropriate dosage and in particular time intervals.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polissacarídeos
/
Proteínas Quinases
/
Encéfalo
/
Lesões Encefálicas
/
Barreira Hematoencefálica
/
Circulação Cerebrovascular
/
Neuroglia
/
Western Blotting
/
Ratos Sprague-Dawley
/
Peroxidase
Limite:
Animais
Idioma:
Inglês
Revista:
Korean Journal of Neurotrauma
Ano de publicação:
2017
Tipo de documento:
Artigo
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