Pathological diagnosis and differential diagnosis of reactive hyperplasia in lymphoid tissues / 白血病·淋巴瘤

ABSTRACT

This paper introduces the clinical features, histopathology, immunophenotype and differential diagnosis of reactive hyperplasia (RH) in lymphoid tissues. The characteristics of RH are as follows (1) Clinical presentations include acute fever and mild enlargement of lymph nodes. The patients can be cured when the causes of disease disappear; (2) Pathological histology is divided into single type and specific type. The common changes of lymphoid tissues are lymph follicle (LF) or T-zone cell hyperplasia, which leads to the disorder of normal tissues, including the increased number of large cells and mitosis (known as the pseudomalignant histological form); (3) Immunophentype is featured by normal pattern of LF and T-zone cells. The key point of differential diagnosis is the overgrowth of cells producing pseudomalignant histological changes in RH, resulting in the lack of cell atypia and monoclonal, damage and erosion of the normal tissue structures.