Clinical analysis of video-assisted thoracoscopic surgery in 65 patients with early non-small cell lung cancer / 中国基层医药

ABSTRACT

Objective@#To study the clinical effect of video-assisted thoracoscopic surgery in the treatment of early non-small cell lung cancer(NSCLC).@*Methods@#130 cases with early NSCLC were selected.According to random number table, the patients were divided into the observation group and the control group, 65 cases in each group.The observation group was treated with video-assisted thoracoscopic surgery, while the control group was treated with thoracotomy.The perioperative period of the two groups was compared, 24h before operation and 24h after operation, the changes of T lymphocyte subsets(CD3+ , CD4+ , CD4+ /CD8+ ) were measured, and the postoperative complications were recorded.The patients were followed up for one year, the survival rate and recurrence rate were recorded.@*Results@#There was no statistically significant difference in the number of lymph node dissection between the two groups(t=1.023, P>0.05). The operation time of the observation group was significantly longer than that of the control group(t=6.479, P<0.05), the amount of bleeding of the observation group was significantly less than that of the control group, the postoperative drainage time and ambulation time of the observation group were significantly shorter than those of the control group, the pain score of the observation group was lower than that of the control group, the differences were statistically significant(t=17.081, 16.040, 39.443, 21.237, all P<0.05). After operation, the CD3+ , CD4+ , CD4+ /CD8+ in the two groups were significantly reduced compared with before operation(observation group t=5.591, 5.300, 4.300; the control group t=10.450, 10.735, 4.883, all P<0.05), the CD3+ , CD4+ , CD4+ /CD8+ of the observation group were significantly higher than those of the control group[(58.95±7.58)% vs.(52.42±7.52)%, (34.83±3.75)% vs.(30.07±3.12)%, (1.21±0.17) vs.(1.15±0.13), t=4.931, 7.867, 2.260, all P<0.05]. The incidence rate of complications of the observation group was significantly lower than that of the control group[6.15%(4/65) vs.18.46%(12/65), χ2=4.561, P<0.05]. The patients were followed up for 1 year, there were no statistically significant differences in survival and recurrence between the two groups(χ2=0.367, 0.208, all P>0.05).@*Conclusion@#Video-assisted thoracoscopic surgery is well for early NSCLC patients, with advantages of small trauma, quick recovery, and it can help to protect the immune function of the organism, the clinical value is high.