Role of Nitric oxide and endothelial nitric oxide synthase in infants with cytomegalovirus hepatitis / 中华实验和临床病毒学杂志

ABSTRACT

Objective@#To investigate the potential clinical role of nitric oxide (NO) and endothelial nitric oxide synthase (eNOS) in infants suffering from infantile cytomegalovirus hepatitis (ICH).@*Methods@#NO and eNOS were measured in 56 ICH infants and 50 healthy controls by using ELISAmethod .@*Results@#NO and eNOS were significantly increased in ICH group as compared with the controls (P<0.01) accompanied by increased ALT in infants of ICH group (P<0.05). Both of NO and eNOS levels were significantly positively correlated with the level of ALT(r=0.682, r=0.746, P<0.05). However, neither NO level nor eNOS level was significantly correlated with the number of copies of HCMV-DNA (r=-0.087, r=-0.134, P>0.05).@*Conclusions@#The expressions of NO and eNOS were significantly increased in infants with human cytomegalovirus hepatitis, and were closely related to the severity of liver lesion.