Prognostic value of neutrophil-to-lymphocyte ratio (NLR) in patients with acute-on-chronic liver failure (ACLF) after glucocorticoid therapy / 中华实验和临床病毒学杂志

ABSTRACT

Objective@#To evaluate the prognostic value of neutrophil-to-lymphocyte ratio (NLR) in patients with acute-on-chronic liver failure (ACLF) after glucocorticoid therapy.@*Methods@#Thirty-six patients with acute-on-chronic liver failure (ACLF) were treated with glucocorticoid therapy, of whom 23 patients in the survival group and the other in the deceased group (n=13). The changes of white blood cells, neutrophils, lymphocytes, NLR, total bilirubin (TBil), prothrombin activity (PTA), international normalized ratio (INR) were observed before, during and after treatment, and the relationship between NLR and prognosis was analyzed.@*Results@#NLR after glucocorticoid treatment, the survival group 3.95±2.65, the deceased group 12.79±10.66, there was significant difference between the two groups (P<0.001). According to univariate and multivariate logisitic regression analysis, NLR ratio was one of the independent factor in ACLF. ROC curve showed the AUC of NLR in patients with ACLF 0.868(95%CI 0.743-0.993). After glucocorticoid treatment, the survival rate of NLR<3.315 patients with acute liver failure was high.@*Conclusions@#NLR is one of the important indexes for evaluating the prognosis of ACLF patients with ACLF due to glucocorticoid therapy.