Radioiodine Therapy in Differentiated Thyroid Cancer: The First Targeted Therapy in Oncology
Endocrinology and Metabolism
;
: 233-239, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-80968
ABSTRACT
Iodide uptake across the membranes of thyroid follicular cells and cancer cells occurs through an active transport process mediated by the sodium-iodide symporter (NIS). The rat and human NIS-coding genes were cloned and identified in 1996. Evaluation of NIS gene and protein expression is critical for the management of thyroid cancer, and several approaches to increase NIS levels have been tried. Identification of the NIS gene has provided a means of expanding its role in radionuclide therapy and molecular target-specific theragnosis (therapy and diagnosis using the same molecular target). In this article, we describe the relationship between NIS expression and the thyroid carcinoma treatment using I-131 and alternative therapeutic approaches.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Glândula Tireoide
/
Transporte Biológico Ativo
/
Neoplasias da Glândula Tireoide
/
Células Clonais
/
Transporte de Íons
/
Diagnóstico
/
Membranas
Tipo de estudo:
Estudo diagnóstico
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Endocrinology and Metabolism
Ano de publicação:
2014
Tipo de documento:
Artigo
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