Effect of hydroxyapatite on critical-sized defect / 대한악안면성형재건외과학회지
Maxillofacial Plastic and Reconstructive Surgery
;
: 26-2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-81067
ABSTRACT
BACKGROUND:
Xenologous or synthetic graft materials are commonly used as an alternative for autografts for guided bone regeneration. The purpose of this study was to evaluate effectiveness of carbonate apatite on the critical-size bone defect of rat's calvarium.METHODS:
Thirty-six critical-size defects were created on 18 adult male Sprague-Dawley rat calvaria under general anesthesia. Calvarial bones were grinded with 8 mm in daimeter bilaterally and then filled with (1) no grafts (control, n = 10 defects), (2) bovine bone mineral (Bio-Oss®, Geistlich Pharma Ag. Swiss, n = 11 defects), and (3) hydroxyapatite (Bongros®, Bio@ Inc., Seongnam, Korea, n = 15 defects). At 4 and 8 weeks after surgery, the rats were sacrificed and all samples were processed for histological and histomorphometric analysis.RESULTS:
At 4 weeks after surgery, group 3 (42.90 ± 9.33 %) showed a significant difference (p < 0.05) compared to the control (30.50 ± 6.05 %) and group 2 (28.53 ± 8.62 %). At 8 weeks after surgery, group 1 (50.21 ± 6.23 %), group 2 (54.12 ± 10.54 %), and group 3 (50.92 ± 6.05 %) showed no significant difference in the new bone formation.CONCLUSIONS:
Bongros®-HA was thought to be the available material for regenerating the new bone formation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteogênese
/
Crânio
/
Regeneração Óssea
/
Carbono
/
Ratos Sprague-Dawley
/
Durapatita
/
Transplantes
/
Autoenxertos
/
Xenoenxertos
/
Mineradores
Limite:
Animais
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Maxillofacial Plastic and Reconstructive Surgery
Ano de publicação:
2016
Tipo de documento:
Artigo
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