A Novel Pancreatic Imaging Window for Stabilized Longitudinal In Vivo Observation of Pancreatic Islets in Murine Model
Diabetes & Metabolism Journal
;
: 193-198, 2020.
Artigo
em Inglês
| WPRIM
| ID: wpr-811136
ABSTRACT
Longitudinal imaging of murine pancreas is technically challenging due to the mechanical softness of the tissue influenced by peristalsis. Here, we report a novel pancreatic imaging window for long-term stabilized cellular-level observation of the islets in the pancreas in vivo. By spatially separating the pancreas from the bowel movement and physiologic respiration with a metal plate integrated in the imaging window, we successfully tracked the pancreatic islets up to three weeks and visualized the dumbbell-shape transformation from the single islet. This window can be a useful tool for long-term cellular-level visualization of the microstructure in the pancreas.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pâncreas
/
Peristaltismo
/
Respiração
/
Ilhotas Pancreáticas
/
Microscopia Intravital
Limite:
Animais
Idioma:
Inglês
Revista:
Diabetes & Metabolism Journal
Ano de publicação:
2020
Tipo de documento:
Artigo
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