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Hypoglycemia and Dementia Risk in Older Patients with Type 2 Diabetes Mellitus: A Propensity-Score Matched Analysis of a Population-Based Cohort Study
Diabetes & Metabolism Journal ; : 125-133, 2020.
Artigo em Inglês | WPRIM | ID: wpr-811142
ABSTRACT

BACKGROUND:

Type 2 diabetes mellitus (T2DM) is associated with an increased risk for dementia. The effects of hypoglycemia on dementia are controversial. Thus, we evaluated whether hypoglycemia increases the risk for dementia in senior patients with T2DM.

METHODS:

We used the Korean National Health Insurance Service Senior cohort, which includes >10% of the entire senior population of South Korea. In total, 5,966 patients who had ever experienced at least one episode of hypoglycemia were matched with those who had not, using propensity score matching. The risk of dementia was assessed through a survival analysis of matched pairs.

RESULTS:

Patients with underlying hypoglycemic events had an increased risk for all-cause dementia, Alzheimer's dementia (AD), and vascular dementia (VaD) compared with those who had not experienced a hypoglycemic event (hazard ratio [HR], 1.254; 95% confidence interval [CI], 1.166 to 1.349; P<0.001 for all-cause dementia; HR, 1.264; 95% CI, 1.162 to 1.375; P<0.001 for AD; HR, 1.286; 95% CI, 1.110 to 1.490; P<0.001 for VaD). According to number of hypoglycemic episodes, the HRs of dementia were 1.170, 1.201, and 1.358 in patients with one hypoglycemic episode, two or three episodes, and more than three episodes, respectively. In the subgroup analysis, hypoglycemia was associated with an increased risk for dementia in both sexes with or without T2DM microvascular or macrovascular complications.

CONCLUSION:

Our findings suggest that patients with a history of hypoglycemia have a higher risk for dementia. This trend was similar for AD and VaD, the two most important subtypes of dementia.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Demência Vascular / Estudos de Coortes / Demência / Diabetes Mellitus Tipo 2 / Pontuação de Propensão / Hipoglicemia / Coreia (Geográfico) / Programas Nacionais de Saúde Tipo de estudo: Estudo de etiologia / Estudo de incidência / Estudo observacional / Fatores de risco Limite: Humanos País/Região como assunto: Ásia Idioma: Inglês Revista: Diabetes & Metabolism Journal Ano de publicação: 2020 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Demência Vascular / Estudos de Coortes / Demência / Diabetes Mellitus Tipo 2 / Pontuação de Propensão / Hipoglicemia / Coreia (Geográfico) / Programas Nacionais de Saúde Tipo de estudo: Estudo de etiologia / Estudo de incidência / Estudo observacional / Fatores de risco Limite: Humanos País/Região como assunto: Ásia Idioma: Inglês Revista: Diabetes & Metabolism Journal Ano de publicação: 2020 Tipo de documento: Artigo