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IL-17-Producing Cells in Tumor Immunity: Friends or Foes?
Immune Network ; : 6-2020.
Artigo em Inglês | WPRIM | ID: wpr-811176
ABSTRACT
IL-17 is produced by RAR-related orphan receptor gamma t (RORγt)-expressing cells including Th17 cells, subsets of γδT cells and innate lymphoid cells (ILCs). The biological significance of IL-17-producing cells is well-studied in contexts of inflammation, autoimmunity and host defense against infection. While most of available studies in tumor immunity mainly focused on the role of T-bet-expressing cells, including cytotoxic CD8⁺ T cells and NK cells, and their exhaustion status, the role of IL-17-producing cells remains poorly understood. While IL-17-producing T-cells were shown to be anti-tumorigenic in adoptive T-cell therapy settings, mice deficient in type 17 genes suggest a protumorigenic potential of IL-17-producing cells. This review discusses the features of IL-17-producing cells, of both lymphocytic and myeloid origins, as well as their suggested pro- and/or anti-tumorigenic functions in an organ-dependent context. Potential therapeutic approaches targeting these cells in the tumor microenvironment will also be discussed.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Células Matadoras Naturais / Linfócitos / Linfócitos T / Autoimunidade / Interleucina-17 / Amigos / Crianças Órfãs / Células Th17 / Microambiente Tumoral / Inflamação Limite: Animais / Humanos Idioma: Inglês Revista: Immune Network Ano de publicação: 2020 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Células Matadoras Naturais / Linfócitos / Linfócitos T / Autoimunidade / Interleucina-17 / Amigos / Crianças Órfãs / Células Th17 / Microambiente Tumoral / Inflamação Limite: Animais / Humanos Idioma: Inglês Revista: Immune Network Ano de publicação: 2020 Tipo de documento: Artigo