Acute Acalculous Cholecystitis Associated with Sunitinib Treatment for Renal Cell Carcinoma / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 103-107, 2020.
Artigo
em Coreano
| WPRIM
| ID: wpr-811440
ABSTRACT
A 64-year-old man was treated with sunitinib as a first-line therapy for metastatic renal cell carcinoma. He was given oral sunitinib in cycles of 50 mg once daily for 2 weeks followed by a week off. During the 5th week of treatment right upper quadrant pain developed, but this resolved spontaneously during the 6th week (off treatment). However, on the 8th week of treatment, he was admitted to hospital because the acute right upper quadrant pain recurred with nausea, vomiting, and fever. Acute acalculous cholecystitis was then diagnosed by ultrasonography and CT. In addition, his laboratory findings indicated disseminated intravascular coagulation. Accordingly, sunitinib therapy was discontinued and broad-spectrum antibiotics initiated. He subsequently recovered after emergent percutaneous cholecystostomy. His Naranjo Adverse Drug Reaction Probability Scale score was 7, indicaing a probable association of the event with sunitinib. Suspicion of sunitinib-related acute cholecystitis is required, because, although uncommon, it can be life-threatening.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Vômito
/
Colecistostomia
/
Carcinoma de Células Renais
/
Ultrassonografia
/
Colecistite Acalculosa
/
Colecistite Aguda
/
Coagulação Intravascular Disseminada
/
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
/
Febre
/
Antibacterianos
Tipo de estudo:
Estudo diagnóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
The Korean Journal of Gastroenterology
Ano de publicação:
2020
Tipo de documento:
Artigo
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