Three new anthraquinone derivatives isolated from Symplocos racemosa and their antibiofilm activity / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 944-949, 2017.
Article
em En
| WPRIM
| ID: wpr-812037
Biblioteca responsável:
WPRO
ABSTRACT
Three new alkyl substituted anthraquinone derivatives, trivially named as symploquinones A-C (Compounds 1-3) were isolated from Symplocos racemosa. The structures of these compounds were determined on the basis of extensive spectroscopic analyses (UV, IR, Mass, H- and C-NMR, and two-dimensional (2D) NMR techniques). The resulting data were also compared with the reported literature. These compounds were then subjected to antibacterial or antibiofilm testing. Compounds 1 and 3 exhibited good antibacterial activity in the concentration range of 160-83 μg·mL against Streptococcus mutans, methicillin resistant Staphylococcus aureus and Proteus mirabilis. Both compounds were further screened for anti-biofilm activity, which revealed promising activities at sub-MIC concentrations. None of the compounds were found to be active against Klebsiella pneumoniae.
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WPRIM
Assunto principal:
Farmacologia
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Fisiologia
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Proteus mirabilis
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Espectrofotometria Infravermelho
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Espectrometria de Massas
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Streptococcus mutans
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Espectroscopia de Ressonância Magnética
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Testes de Sensibilidade Microbiana
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Química
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Antraquinonas
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2017
Tipo de documento:
Article