New diterpenoids isolated from Leonurus japonicus and their acetylcholinesterase inhibitory activity / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 860-864, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-812048
ABSTRACT
Three new labdane diterpenoids, leojaponicone A (1), isoleojaponicone A (2) and methylisoleojaponicone A (3), were isolated from the herb of Leonurus japonicus. The chemical structures of these secondary metabolites were elucidated on the basis of 1D and 2D NMR, including HMQC, and HMBC spectroscopic techniques. All the new compounds were tested in vitro for their acetylcholinesterase and α-glucosidase inhibitory activity. Compounds 1-3 exhibited low inhibitory effects on α-glucosidase with respect to acarbose and exhibited high inhibitory effects on acetylcholinesterase with respect to huperzine A.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Acetilcolinesterase
/
Extratos Vegetais
/
Espectroscopia de Ressonância Magnética
/
Estrutura Molecular
/
Química
/
Inibidores da Colinesterase
/
Leonurus
/
Diterpenos
/
Inibidores de Glicosídeo Hidrolases
Idioma:
Inglês
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2017
Tipo de documento:
Artigo
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