Anti-colorectal cancer effects of tripolinolate A from Tripolium vulgare / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 576-583, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-812079
ABSTRACT
Tripolinolate A (TLA) is recently identified as a new compound from a halophyte plant Tripolium vulgare and has been shown to have significant in vitro activity against the proliferation of colorectal cancer and glioma cells. This study was designed to further investigate the effects of TLA on the proliferation of human normal cells, and the apoptosis and cell cycle in colorectal cancer cells, and the growth of tumors in the colorectal cancer-bearing animals. The data obtained from this study demonstrated that 1) TLA had much less cytotoxicity in the human normal cells than the colorectal cancer cells; 2) TLA remarkably induced apoptosis in the human colorectal cancer cells and blocked cell cycle at G/M phase, and 3) TLA had significant anti-colorectal cancer activity in the tumor-bearing animals.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenóis
/
Medicamentos de Ervas Chinesas
/
Neoplasias Colorretais
/
Química
/
Fase G2
/
Apoptose
/
Asteraceae
/
Linhagem Celular Tumoral
/
Proliferação de Células
/
Tratamento Farmacológico
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2017
Tipo de documento:
Artigo
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