Pharmacology of mangostins and their derivatives: A comprehensive review / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 81-93, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-812129
ABSTRACT
Mangosteen (Garcinia mangostana Linn.) is a well-known tropical tree indigenous to Southeast Asia. Its fruit's pericarp abounds with a class of isoprenylated xanthones which are referred as mangostins. Numerous in vitro and in vivo studies have shown that mangostins and their derivatives possess diverse pharmacological activities, such as antibacterial, antifungal, antimalarial, anticarcinogenic, antiatherogenic activities as well as neuroprotective properties in Alzheimer's disease (AD). This review article provides a comprehensive review of the pharmacological activities of mangostins and their derivatives to reveal their promising utilities in the treatment of certain important diseases, mainly focusing on the discussions of the underlying molecular targets/pathways, modes of action, and relevant structure-activity relationships (SARs). Meanwhile, the pharmacokinetics (PK) profile and recent toxicological studies of mangostins are also described for further druggability exploration in the future.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Extratos Vegetais
/
Fármacos Cardiovasculares
/
Química
/
Anticarcinógenos
/
Fármacos Neuroprotetores
/
Substâncias Protetoras
/
Garcinia mangostana
/
Xantonas
/
Frutas
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2017
Tipo de documento:
Artigo
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