A new quinoline alkaloid from the roots of Dictamnus angustifolius / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 222-224, 2014.
Article
em En
| WPRIM
| ID: wpr-812282
Biblioteca responsável:
WPRO
ABSTRACT
AIM@#To investigate the quinoline alkaloids from the roots of Dictamnus angustifolius G.Don ex Sweet (Rutaceae).@*METHOD@#The quinoline alkaloids were isolated by various column chromatographic methods and their structures were elucidated on the basis of spectral analysis.@*RESULTS@#A new quinoline alkaloid, 5-methoxylrobustine (1), along with five known quinoline alkaloids were obtained, and their structures were identified as dictamnine (2), robustine (3), isopteleine (4), γ-fagarine (5), and skimmianine (6). Cytotoxicity testing of these alkaloids showed that all of them had weak cytotoxic activities against human breast cancer cells (MCF7).@*CONCLUSION@#Compound 1 is a new quinoline alkaloid. Alkaloid 3 showed stronger anti-proliferation effect than the other alkaloids.
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Assunto principal:
Farmacologia
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Quinolinas
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Neoplasias da Mama
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Extratos Vegetais
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Estrutura Molecular
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Química
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Raízes de Plantas
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Dictamnus
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Linhagem Celular Tumoral
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Usos Terapêuticos
Limite:
Humans
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2014
Tipo de documento:
Article