Histological and ultrastructural studies on the toxic effect of pan masala and its amelioration by Elettaria cardamomum / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 199-203, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-812286
ABSTRACT
AIM@#To investigate the histological and ultrastructural changes observed in pan masala intoxicated mammalian testes under the effect of cardamom.@*METHODS@#Male Swiss mice were given pan masala orally at a dose of 2% of the feed and cardamom at a dose of 0.2% of the feed. They were divided into three groups, control (Group I), pan masala-treated (Group II), and a combination of pan masala and cardamom-treated group (Group III). Histologically, the testes of Group II mice displayed degeneration of tubular epithelium, disruption of spermatogenesis, and a marked reduction in germ cells.@*RESULTS@#When cardamom was given, damage was less with fewer distorted cells and also improvement with normal tubules and spermatid differentiation in Group III. Ultrastructurally, pan masala-treated testes showed cytoplasmic vacuolation, shrinkage and pyknotic nuclei of spermatogonia, and abnormal acrosomal granules.@*CONCLUSION@#When cardamom was given, the amelioration process was more evident showing a comparable morphology with control.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Areca
/
Espermatogênese
/
Espermatozoides
/
Doenças Testiculares
/
Testículo
/
Nicotiana
/
Vacúolos
/
Extratos Vegetais
Limite:
Animais
Idioma:
Inglês
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2014
Tipo de documento:
Artigo
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