The identification and pharmacokinetic studies of metabolites of salvianolic acid B after intravenous administration in rats / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 560-565, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-812320
ABSTRACT
AIM@#To identify and quantify the major metabolites of salvianolic acid B (SAB) after intravenous injection in rats.@*METHODS@#LC-IT/TOF-MS was used to identify the metabolites in rat bile, plasma, and urine; LC-MS/MS was used to quantify the two major metabolites.@*RESULTS@#In rat bile, plasma, and urine, nine metabolites were identified, including methylated metabolites of SAB, lithospermic acid (LSA), the decarboxylation and methylation metabolites of LSA, salvianolic acid S (SAS), and dehydrated-SAS. The t1/2 of monomethyl-SAB and LSA were both very short, and monomethyl-SAB had a larger AUC than LSA in rats.@*CONCLUSION@#Nine metabolites were found, the metabolic pathway was described, and the pharmacokinetic profiles of LSA and monomethyl-SAB were studied, thereby clarifying that methylation was the dominant metabolic pathway for SAB in rats.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasma
/
Urina
/
Benzofuranos
/
Bile
/
Farmacocinética
/
Estrutura Molecular
/
Química
/
Ratos Sprague-Dawley
/
Administração Intravenosa
/
Metabolismo
Tipo de estudo:
Estudo diagnóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2013
Tipo de documento:
Artigo
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