Design, synthesis, and biological evaluation of novel nitric oxide releasing dehydroandrographolide derivatives / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 782-790, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-812350
ABSTRACT
A series of new hybrids of dehydroandrographolide (TAD), a biologically active natural product, bearing nitric oxide (NO)-releasing moieties were synthesized and designated as NO-donor dehydroandrographolide. The biological activities of target compounds were studied in human erythroleukemia K562 cells and breast cancer MCF-7 cells. Biological evaluation indicated that the most active compound I-5 produced high levels of NO and inhibited the proliferation of K562 (IC 1.55 μmol·L) and MCF-7 (IC 2.91 μmol·L) cells, which were more potent than the lead compound TAD and attenuated by an NO scavenger. In conclusion, I-5 is a novel hybrid with potent antitumor activity and may become a promising candidate for future intensive study.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Relação Estrutura-Atividade
/
Ensaios de Seleção de Medicamentos Antitumorais
/
Desenho de Fármacos
/
Química
/
Células K562
/
Proliferação de Células
/
Diterpenos
/
Células MCF-7
/
Antineoplásicos
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2018
Tipo de documento:
Artigo
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