Fumigaclavine I, a new alkaloid isolated from endophyte Aspergillus terreus / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 937-941, 2015.
Article
em En
| WPRIM
| ID: wpr-812461
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WPRO
ABSTRACT
The present study was designed to isolate and purify chemical constituents from solid culture of endophyte Aspergillus terreus LQ, using silica gel column chromatography, gel filtration with Sephadex LH-20, and HPLC. Fumigaclavine I (1), a new alkaloid, was obtained, along with seven known compounds, including fumigaclavine C (2), rhizoctonic acid (3), monomethylsulochrin (4), chaetominine (5), spirotryprostatin A (6), asperfumoid (7), and lumichrome (8). The structure of compound 1 was elucidated by various spectroscopic analyses (UV, MS, 1D and 2D NMR). The in vitro cytotoxicity of compound 1 was determined by MTT assay in human hepatocarcinoma cell line SMMC-7721, showing weaker cytotoxicity, compared with cisplatin, a clinically used cancer chemotherapeutic agent.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Aspergillus
/
Oryza
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Espectroscopia de Ressonância Magnética
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Estrutura Molecular
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Sobrevivência Celular
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Química
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Linhagem Celular Tumoral
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Alcaloides de Claviceps
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Endófitos
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Microbiologia
Limite:
Humans
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2015
Tipo de documento:
Article