Cancer therapy using natural ligands that target estrogen receptor beta / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 801-807, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-812478
ABSTRACT
Estrogen receptor beta (ERβ) is one of the two key receptors (ERα, ERβ) that facilitate biological actions of 17β-estradiol (E2). ERβ is widely expressed in many tissues, and its expression is reduced or lost during progression of many tumors. ERβ facilitates estrogen signaling by both genomic (classical and non-classical) and extra-nuclear signaling. Emerging evidence suggests that ERβ functions as a tissue-specific tumor suppressor with anti-proliferative actions. Recent studies have identified a number of naturally available selective ERβ agonists. Targeting ERβ using its naturally available ligands is an attractive approach for treating and preventing cancers. This review presents the beneficial actions of ERβ signaling and clinical utility of several natural ERβ ligands as potential cancer therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Glycine max
/
Extratos Vegetais
/
Química
/
Genisteína
/
Flavanonas
/
Usos Terapêuticos
/
Receptor beta de Estrogênio
/
Tratamento Farmacológico
/
Equol
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2015
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS