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Synthesis of 13-β-elemene ester derivatives and evaluation of their antioxidant activity in human umbilical vein endothelial cells / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.) ; (6): 618-627, 2015.
Artigo em Inglês | WPRIM | ID: wpr-812503
ABSTRACT
In the present study, a series of 13-β-elemene ester derivatives were designed and prepared, and their antioxidant activity was investigated in the H2O2-treated human umbilical vein endothelial cells (HUVECs). Among the test compounds, the dimer compounds 5v and 5w exhibited the most potent antioxidant activity with significant ROS suppression being observed. Both compounds markedly inhibited the H2O2-induced changes in various biochemical substances, such as superoxide dismutase (SOD), malonyldialdehyde (MDA), nitric oxide (NO), and lactic dehydrogenase (LDH), which were superior to that of the positive control vitamin E. Further more, they did not produce any obvious cytotoxicity, but increased the viability of HUVECs injured by H2O2 in a dose-dependent manner. Additionally, compound 5w, designed as a prodrug-like compound, showed improved stability relative to compound 4 in vitro.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Oxirredução / Farmacologia / Ácidos Ftálicos / Sesquiterpenos / Succinatos / Superóxido Dismutase / Medicamentos de Ervas Chinesas / Endotélio Vascular / Células Cultivadas / Química Limite: Humanos Idioma: Inglês Revista: Chinese Journal of Natural Medicines (English Ed.) Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Oxirredução / Farmacologia / Ácidos Ftálicos / Sesquiterpenos / Succinatos / Superóxido Dismutase / Medicamentos de Ervas Chinesas / Endotélio Vascular / Células Cultivadas / Química Limite: Humanos Idioma: Inglês Revista: Chinese Journal of Natural Medicines (English Ed.) Ano de publicação: 2015 Tipo de documento: Artigo