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Pharmacokinetics and tissue distributions of veratric acid after intravenous administration in rats / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.) ; (6): 535-539, 2015.
Artigo em Inglês | WPRIM | ID: wpr-812513
ABSTRACT
The present study was designed to investigate the pharmacokinetics and tissue distributions of veratric acid following intravenous administration in rats. The concentrations of veratric acid in rat plasma at various times after administrated at doses of 2.5, 5, and 10 mg·kg(-1) were quantified by HPLC. The tissue distributions of veratric acid at various times after a single intravenous dose of 2.5 mg·kg(-1) were also analyzed. The plasma pharmacokinetic parameters at the three doses were as follows t(1/2), (86.23 ± 6.83), (72.66 ± 4.10) and (71.20 ± 2.90) min; C0, (11.10 ± 1.47), (23.67 ± 1.24) and (39.17 ± 3.90) μg·mL(-1); and AUC(0→∞), (1 240.90 ± 129.14), (2 273.84 ± 132.47) and (3 516.4 ± 403.37) min·μg·mL(-1), respectively. The compound was distributed into tissues rapidly and extensively after intravenous administration and was mainly distributed into the liver, heart and kidneys.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Ácido Vanílico / Farmacocinética / Extratos Vegetais / Distribuição Tecidual / Química / Ratos Sprague-Dawley / Ranunculaceae / Administração Intravenosa / Rim / Fígado Limite: Animais Idioma: Inglês Revista: Chinese Journal of Natural Medicines (English Ed.) Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Ácido Vanílico / Farmacocinética / Extratos Vegetais / Distribuição Tecidual / Química / Ratos Sprague-Dawley / Ranunculaceae / Administração Intravenosa / Rim / Fígado Limite: Animais Idioma: Inglês Revista: Chinese Journal of Natural Medicines (English Ed.) Ano de publicação: 2015 Tipo de documento: Artigo