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Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.) ; (6): 15-40, 2017.
Artigo em Inglês | WPRIM | ID: wpr-812552
ABSTRACT
Wogonin is a plant flavonoid compound extracted from Scutellaria baicalensis (Huang-Qin or Chinese skullcap) and has been studied thoroughly by many researchers till date for its anti-viral, anti-oxidant, anti-cancerous and neuro-protective properties. Numerous experiments conducted in vitro and in vivo have demonstrated wogonin's excellent tumor inhibitory properties. The anti-cancer mechanism of wogonin has been ascribed to modulation of various cell signaling pathways, including serine-threonine kinase Akt (also known as protein kinase B) and AMP-activated protein kinase (AMPK) pathways, p53-dependent/independent apoptosis, and inhibition of telomerase activity. Furthermore, wogonin also decreases DNA adduct formation with a carcinogenic compound 2-Aminofluorene and inhibits growth of drug resistant malignant cells and their migration and metastasis, without any side effects. Recently, newly synthesized wogonin derivatives have been developed with impressive anti-tumor activity. This review is the succinct appraisal of the pertinent articles on the mechanisms of anti-tumor properties of wogonin. We also summarize the potential of wogonin and its derivatives used alone or as an adjunct therapy for cancer treatment. Furthermore, pharmacokinetics and side effects of wogonin and its analogues have also been discussed.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Medicamentos de Ervas Chinesas / Transdução de Sinais / Química / Adutos de DNA / Resistencia a Medicamentos Antineoplásicos / Scutellaria baicalensis / Flavanonas / Usos Terapêuticos / Tratamento Farmacológico Limite: Animais / Humanos Idioma: Inglês Revista: Chinese Journal of Natural Medicines (English Ed.) Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Medicamentos de Ervas Chinesas / Transdução de Sinais / Química / Adutos de DNA / Resistencia a Medicamentos Antineoplásicos / Scutellaria baicalensis / Flavanonas / Usos Terapêuticos / Tratamento Farmacológico Limite: Animais / Humanos Idioma: Inglês Revista: Chinese Journal of Natural Medicines (English Ed.) Ano de publicação: 2017 Tipo de documento: Artigo