Diversity synthesis of tetrahydroprotoberberines glycosides by combined chemical and microbial catalysis / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 783-788, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-812557
ABSTRACT
The present study was designed to construct the structurally diverse library of tetrahydroprotoberberines (THPBs) by combining the methods of chemical nonselective demethylation and microbial glycosylation. HPLC-MS/MS analyses tentatively identified 12 de-methylated and 9 glycosylated derivates of THPBs and 5 rarely oxidized glycosides of THPBs in the library. Through this effort, we achieved not only a variety of the THPBs and their glycosides but also tested the catalytic characteristics and capabilities of G. deliquescens NRRL 1086.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Alcaloides de Berberina
/
Glicosilação
/
Biotransformação
/
Estrutura Molecular
/
Catálise
/
Química
/
Gliocladium
/
Glicosídeos
/
Metabolismo
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2016
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS