Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 427-433, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-812614
ABSTRACT
Cranberry extract (CBE) rich in polyphenols are potent to delay paralysis induced by alleviating β-amyloid (Aβ) toxicity in C. elegans model of Alzheimer's disease (AD). In order to better apply CBE as an anti-AD agent efficiently, we sought to deterrmine whether preventive or therapeutic effect contributes more prominently toward CBE's anti-AD activity. As the level of Aβ toxicity and memory health are two major pathological parameters in AD, in the present study, we compared the effects of CBE on Aβ toxicity and memory health in the C. elegans AD model treated with preventive and therapeutic protocols. Our results revealed that CBE prominently showed the preventive efficacy, providing a basis for further investigation of these effects in mammals.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Psicologia
/
Extratos Vegetais
/
Química
/
Peptídeos beta-Amiloides
/
Caenorhabditis elegans
/
Suplementos Nutricionais
/
Vaccinium macrocarpon
/
Modelos Animais de Doenças
/
Tratamento Farmacológico
/
Toxicidade
Tipo de estudo:
Guia de Prática Clínica
/
Estudo prognóstico
Limite:
Animais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2016
Tipo de documento:
Artigo
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