Two novel resin glycosides isolated from Ipomoea cairica with α-glucosidase inhibitory activity / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 227-231, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-812632
ABSTRACT
In the present study, two new compounds from Ipomoea cairica were identified and demonstrated to have α-glucosidase inhibitory activity. They were isolated by column chromatography on silica gel and sephadex LH-20 and finally purified by prep-HPLC, with their structures being elucidated by spectroscopic methods, such as 1D- and 2D-NMR and HR-TOF-MS, and chemical methods. Compounds 1 and 2, named cairicoside A and cairicoside B, were evaluated for α-glucosidase inhibitory activity by the MTT method, with the IC50 values being 25.3 ± 1.6 and 28.5 ± 3.3 μmol·L(-1), respectively.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Resinas Vegetais
/
Análise Espectral
/
Extratos Vegetais
/
Estrutura Molecular
/
Química
/
Ipomoea
/
Alfa-Glucosidases
/
Inibidores de Glicosídeo Hidrolases
Idioma:
Inglês
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2016
Tipo de documento:
Artigo
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