Ameliorating effect of new constituents from the hooks of Uncaria rhynchophylla on scopolamine-induced memory impairment / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 391-395, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-812664
ABSTRACT
AIM@#To study the chemical constituents and their anti-amnesic effect from the hooks of Uncaria rhynchophylla.@*METHODS@#The isolation of compounds was performed by chromatographic techniques and their structures were identified on the basis of spectral analysis. Their ameliorating effects on scopolamine-induced memory impairment in vivo using a Morris water-maze task and passive avoidance task system were evaluated.@*RESULTS@#Activity-guided fractionation of the total extracts resulted in the isolation of four constituents, trans-anethole (1), p-anisaldehyde (2), estragole (3), and 3-oxo-olean-12-en-28-oic acid (4), which were found for the first time from this plant.@*CONCLUSION@#Compound 1 exhibited a better memory enhancing effect than tacrine, a positive agent, at the same dose in the passive avoidance test and a similar property in the water-maze test, and its action may be mediated, in part, by the acetylcholine enhancing cholinergic nervous system.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Escopolamina
/
Extratos Vegetais
/
Estrutura Molecular
/
Química
/
Ratos Sprague-Dawley
/
Uncaria
/
Tratamento Farmacológico
/
Memória
/
Transtornos da Memória
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2013
Tipo de documento:
Artigo
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