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Ameliorating effect of new constituents from the hooks of Uncaria rhynchophylla on scopolamine-induced memory impairment / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.) ; (6): 391-395, 2013.
Artigo em Inglês | WPRIM | ID: wpr-812664
ABSTRACT
AIM@#To study the chemical constituents and their anti-amnesic effect from the hooks of Uncaria rhynchophylla.@*METHODS@#The isolation of compounds was performed by chromatographic techniques and their structures were identified on the basis of spectral analysis. Their ameliorating effects on scopolamine-induced memory impairment in vivo using a Morris water-maze task and passive avoidance task system were evaluated.@*RESULTS@#Activity-guided fractionation of the total extracts resulted in the isolation of four constituents, trans-anethole (1), p-anisaldehyde (2), estragole (3), and 3-oxo-olean-12-en-28-oic acid (4), which were found for the first time from this plant.@*CONCLUSION@#Compound 1 exhibited a better memory enhancing effect than tacrine, a positive agent, at the same dose in the passive avoidance test and a similar property in the water-maze test, and its action may be mediated, in part, by the acetylcholine enhancing cholinergic nervous system.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Escopolamina / Extratos Vegetais / Estrutura Molecular / Química / Ratos Sprague-Dawley / Uncaria / Tratamento Farmacológico / Memória / Transtornos da Memória Limite: Animais / Humanos / Masculino Idioma: Inglês Revista: Chinese Journal of Natural Medicines (English Ed.) Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Escopolamina / Extratos Vegetais / Estrutura Molecular / Química / Ratos Sprague-Dawley / Uncaria / Tratamento Farmacológico / Memória / Transtornos da Memória Limite: Animais / Humanos / Masculino Idioma: Inglês Revista: Chinese Journal of Natural Medicines (English Ed.) Ano de publicação: 2013 Tipo de documento: Artigo