Synthesis and in vitro cytotoxicity evaluation of baicalein amino acid derivatives / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 284-288, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-812691
ABSTRACT
AIM@#To synthesize the baicalein amino acid derivatives and evaluate their cytotoxicity activities in vitro.@*METHODS@#Amino acids were subjected to methylation and aminoacylation reaction, then reacted with formaldehyde and baicalein to synthesize baicalein-8 benzyl amino acid derivatives. Through carboxyl group protection and aminoacylation of amino acid and benzyl protection of baicalein, derivatives of baicalein-6-O-amino acid esters were obtained. All of the target compounds were identified by IR, MS and (1)H NMR.@*RESULTS@#Thirteen novel derivatives were synthesized and characterized. Their cytotoxic activities were assessed by the MTT method on the inhibition of HepG2 cells in vitro.@*CONCLUSION@#Compounds 4c, 4d, 7a and 7b showed a significant increase in cytotoxicity compared with baicalein.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Acilação
/
Estrutura Molecular
/
Química
/
Flavanonas
/
Proliferação de Células
/
Toxicidade
/
Células Hep G2
/
Aminoácidos
/
Metilação
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2013
Tipo de documento:
Artigo
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