Synthesis of A B C-ring subunit of C-nor-D-homo-steroidal alkaloids: towards the total synthesis of cyclopamine / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 277-283, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-812692
ABSTRACT
A practical approach to the synthesis of the A, B and C-ring subunit of cyclopamine has been developed. This synthetic tactic highlights the utility of mandelate acetal-mediated resolution of the fused ring ketone (±)-4 and IBX-mediated oxidation cascades from 12 to 9. The availability of advanced intermediates from enantiomerically pure (+)-4 and 2 could provide efficient access to biologically active and structurally diverse C-nor-D-homo-steroidal alkaloids such as cyclopamine.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Estereoisomerismo
/
Esteroides
/
Alcaloides de Veratrum
/
Estrutura Molecular
/
Química
/
Fenômenos de Química Orgânica
/
Técnicas de Química Sintética
/
Métodos
Idioma:
Inglês
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2013
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS