Role of adiponectin in prostate cancer: A preliminary study / 中华男科学杂志
National Journal of Andrology
; (12): 975-981, 2017.
Article
em Zh
| WPRIM
| ID: wpr-812847
Biblioteca responsável:
WPRO
ABSTRACT
Objective@#To investigate the relationship of the serum adiponectin level with the development of prostate cancer (PCa) and its influence on the biological characteristics of PCa cells.@*METHODS@#This retrospective case-control study included 45 cases of PCa and 50 non-PCa controls. We analyzed the relationship of the serum adiponectin level with the development of PCa. Using the lentiviral vector, we constructed a stably transfected cell line with adiponectin receptor deficiency, treated the PCa cells with adiponectin, and determined the influence of the adiponectin level on the biological behavior of the PC-3 cells by CCK-8 assay, flow cytometry, tube formation assay and scratch wound healing assay.@*RESULTS@#The level of serum adiponectin was decreased in the PCa patients as compared with the controls and it was negatively correlated with the Gleason scores. Adiponectin suppressed the proliferation, migration and tube formation of the PC-3 cells and inhibited them from transforming into S-stage cells. In the condition of adiponectin receptor deficiency, the PC-3 cells exhibited even greater abilities of proliferation, migration and pro-angiogenesis.@*CONCLUSIONS@#The decreased level of the serum adiponectin or deficiency of adiponectin receptor may contribute to the development of prostate cancer.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Neoplasias da Próstata
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Sangue
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Transfecção
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Estudos de Casos e Controles
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Estudos Retrospectivos
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Linhagem Celular Tumoral
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Proliferação de Células
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Adiponectina
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Receptores de Adiponectina
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Gradação de Tumores
Tipo de estudo:
Observational_studies
Limite:
Humans
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Male
Idioma:
Zh
Revista:
National Journal of Andrology
Ano de publicação:
2017
Tipo de documento:
Article