TDP-43 in male infertility: Progress in studies / 中华男科学杂志
National Journal of Andrology
; (12): 942-945, 2017.
Article
em Zh
| WPRIM
| ID: wpr-812851
Biblioteca responsável:
WPRO
ABSTRACT
Approximately 10-15% of couples worldwide fail to achieve a pregnancy within a year after marriage. Male factors account for about 50% of the causes of infertility and the causes of male infertility are complicated and varied, and many of them are not yet clear. In recent years, the role of RNA-binding proteins in male infertility has attracted much attention. The transactive response DNA-binding protein of 43 kDa (TDP-43) is involved in gene regulation in the testis, and its abnormal expression may affect male reproduction and lead to male infertility. The distribution and expression of TDP-43 vary in normal and abnormal spermatozoa and may be a marker of male infertility. This article presents an overview on the structure of TDP-43 and its role in male infertility.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Espermatozoides
/
Testículo
/
Regulação da Expressão Gênica
/
Proteínas de Ligação a RNA
/
Proteínas de Ligação a DNA
/
Infertilidade Masculina
/
Metabolismo
Limite:
Humans
/
Male
Idioma:
Zh
Revista:
National Journal of Andrology
Ano de publicação:
2017
Tipo de documento:
Article