TDP-43 in male infertility: Progress in studies / 中华男科学杂志
National Journal of Andrology
;
(12): 942-945, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-812851
ABSTRACT
Approximately 10-15% of couples worldwide fail to achieve a pregnancy within a year after marriage. Male factors account for about 50% of the causes of infertility and the causes of male infertility are complicated and varied, and many of them are not yet clear. In recent years, the role of RNA-binding proteins in male infertility has attracted much attention. The transactive response DNA-binding protein of 43 kDa (TDP-43) is involved in gene regulation in the testis, and its abnormal expression may affect male reproduction and lead to male infertility. The distribution and expression of TDP-43 vary in normal and abnormal spermatozoa and may be a marker of male infertility. This article presents an overview on the structure of TDP-43 and its role in male infertility.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Espermatozoides
/
Testículo
/
Regulação da Expressão Gênica
/
Proteínas de Ligação a RNA
/
Proteínas de Ligação a DNA
/
Infertilidade Masculina
/
Metabolismo
Limite:
Humanos
/
Masculino
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2017
Tipo de documento:
Artigo
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