Sperm mitochondrial DNA and male infertility: An update / 中华男科学杂志
National Journal of Andrology
;
(12): 848-851, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-812867
ABSTRACT
Sperm mitochondrial DNA (mtDNA) damage is closely related with male infertility. Lacking for the protection by histone and DNA-binding protein, sperm mtDNA is prone to the attack by reactive oxygen species (ROS) and, without an effective repair system of mtDNA, ROS-induced changes in mtDNA may damage the synthesis of mtDNA encoding proteins and affect the function of mitochondria, which may be an important genetic factor for male infertility. Related studies should focus on finding the causes of sperm mtDNA damage and its relationship with male infertility.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Espermatozoides
/
Dano ao DNA
/
DNA Mitocondrial
/
Espécies Reativas de Oxigênio
/
Estresse Oxidativo
/
Genética
/
Infertilidade Masculina
/
Mitocôndrias
Limite:
Humanos
/
Masculino
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2017
Tipo de documento:
Artigo
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