The clinical significance of gene mutation detection in myelodysplastic syndromes / 天津医药
Tianjin Medical Journal
;
(12): 808-810, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-812955
ABSTRACT
@#Myelodysplastic syndrome (MDS), a clonal disease that arises from the expansion of mutated hematopoietic stem cells or hematopoietic progenitor cells, is usually characterized by a clinically and biologically heterogeneous group of disorders associated with cytopenias, ineffective hematopoiesis, and a tendency to evolve into acute myeloid leukemia. Currently, the diagnosis of MDS relies mainly on the morphologic and cytogenetic abnormalities. With the advance of the next generation sequencing, genetic mutations have been identified in majority of MDS patients. Here we briefly review the clinical significance of genetic mutations in the diagnosis, classification, risk stratification and treatment of MDS.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo diagnóstico
Idioma:
Chinês
Revista:
Tianjin Medical Journal
Ano de publicação:
2018
Tipo de documento:
Artigo
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