The role of liver sinusoidal endothelial cells in the progression of nonalcoholic fatty liver disease / 临床肝胆病杂志

ABSTRACT

Nonalcoholic fatty liver disease (NAFLD) is a clinical metabolic syndrome characterized by hepatic steatosis, inflammation, and fibrosis and has become a common chronic liver disease with great impact on public health. Liver sinusoidal endothelial cells (LSECs) are specialized vascular endothelium of liver tissue, and as an important vascular barrier, LSECs play an important role in regulating the absorption and metabolism of nutrients and substances from the blood of the intestines in hepatocytes. This article reviews the research advances in LSEC capillarization, vascular dysfunction, and its involvement in the regulation of liver inflammation, angiogenesis, and liver fibrosis during the development and progression of NAFLD.