Microvessel counts and the expressions of chemotactic factors in the pathological scar tissues / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 340-348, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-813366
ABSTRACT
OBJECTIVE@#To explore the microvessel counts and the expressions of interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-1 ( MIP-1) alpha mRNA in the pathological scar tissues.@*METHODS@#Immunohistochemical method of avidin-biotin complex was used for microvessel counts on the routinely formalin-fixed and paraffin-embedded sections of specimens of hypertrophic scars, keloids, normal skin, and surgical scar, and in situ hybridization for the expressions of IL-8, MCP-1, MIP-1alpha mRNA.@*RESULTS@#The microvessel counts as well as the positive rates and the scorings of IL-8, MCP-1, and MIP-1alpha mRNA were significantly higher in pathological scars than those in the normal skin and surgical scar (all P < 0.05). The microvessel counts were significantly higher in the positive cases of IL-8, MCP-1 and MIP-1alpha mRNA than those in the negative ones (P < 0.05). The close positive correlations were found among the microvessel counts and the expressive scorings of 3 factors (P < 0.05). The close positive correlations were also found among the expressive scorings of IL-8, MCP-1, and MIP-1alpha mRNA in pathological scars. Microvessel counts were significantly higher in hypertrophic scars with the course less than 1 year than those with the course more than 1 year.@*CONCLUSION@#IL-8, MCP-1 and MIP-1alpha play important roles in promoting the neovascularization of pathological scars.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pele
/
Queimaduras
/
Capilares
/
RNA Mensageiro
/
Interleucina-8
/
Cicatriz
/
Quimiocina CCL2
/
Proteínas Inflamatórias de Macrófagos
/
Quimiocina CCL3
/
Quimiocina CCL4
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2005
Tipo de documento:
Artigo
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