Cytogenetic study of 1780 cases of spontaneous abortion / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 258-260, 2005.
Article
em Zh
| WPRIM
| ID: wpr-813387
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To explore the relationship between chromosome anomaly and spontaneous abortion, and to provide useful information for genetic counseling and prenatal diagnosis in reproductive clinic.@*METHODS@#A total of 1 780 patients who had a history of spontaneous abortion before 24 weeks of gestation were enrolled. The lymphocyte culture and harvest were performed according to standard methods. Karyotypes were analyzed by G-banding in all cases and C- banding in some cases in addition.@*RESULTS@#Altogether 57 abnormal karyotypes were found and the overall incidence of chromosomal abnormalities was 3.20% (women 3.32%; men 2.12%). Among them 23 cases were the balanced translocation; 14 cases were the Robertsonian translocation, 3 cases were the complex chromosomal rearrangement, and the other 17 cases were the other abnormalities. In women with 1, 2, 3 or more spontaneous abortion, the incidence of chromosomal abnormalities was 1.7%, 2.3%, and 5.8%, respectively.@*CONCLUSION@#Translocations are the major abnormal karyotpes associated with spontaneous abortions. The chance of finding chromosomal aberration increases with the number of abortions. Chromosomal abnormalities are more common in women with 3 or more spontaneous abortions.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Patologia
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Diagnóstico Pré-Natal
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Translocação Genética
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Aborto Espontâneo
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Aberrações Cromossômicas
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Análise Citogenética
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Genética
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Cariotipagem
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
Zh
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2005
Tipo de documento:
Article