Inhibitory effect of reinioside C on LOX-1 expression induced by ox-LDL / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 659-662, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-813626
ABSTRACT
OBJECTIVE@#To investigate the effect of reinioside C (RC) on the expression of lectin-like oxidized low density lipoprotein receptor (LOX)-1 mRNA and LOX-1 protein induced by oxidized low density lipoprotein (ox-LDL) in cultured human umbilical vein endothelial cells (HUVEC).@*METHODS@#HUVECs were cultured with ox-LDL (50 mg/L) for 24 h in the absence or presence of RC (1, 3, and 10 micromol/L). The expressions of LOX-1 mRNA and LOX-1 protein were examined by RT-PCR and Western-blot.@*RESULTS@#Incubation with ox-LDL (50 mg/L) significantly raised the expression of LOX-1 mRNA and LOX-1 protein,which was concentration-dependent.@*CONCLUSION@#RC can inhibit the increased expression of LOX-1 mRNA and LOX-1 protein induced by ox-LDL in HUVECs.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Saponinas
/
Veias Umbilicais
/
RNA Mensageiro
/
Receptores de LDL
/
Medicamentos de Ervas Chinesas
/
Endotélio Vascular
/
Células Cultivadas
/
Química
/
Biologia Celular
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2006
Tipo de documento:
Artigo
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