Anti-oxidant effects of Tongxinluo on ATPase in focal brain ischemia-reperfusion rats / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 552-555, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-813653
ABSTRACT
OBJECTIVE@#To explore the effects of Tongxinluo on adenosine triphosphatase (ATPase), anti-oxidant enzymes activities, and lipid peroxidation of mitochondria or brain homogenate in focal brain ischemia-reperfusion rats.@*METHODS@#The models of the focal brain ischemia-reperfusion rats were made by the middle cerebral artery occlusion (MCAO). Activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and ATPase and malonaldehyde (MDA) levels of mitochondria or brain homogenate were measured by biochemical methods.@*RESULTS@#Tongxinluo significantly inhibited the decrease of activities of SOD and the increase of MDA levels, but had no difference in GSH-Px in brain homogenate. It also inhibited the decrease of activities of SOD, GSH-Px, ATPase, and the increase of MDA levels in mitochondria.@*CONCLUSION@#The protective mechanisms of Tongxinluo against mitochondrial injuries in focal ischemia-reperfusion rats may be derived from reducing lipid peroxides, scavenging free radicals and improving the energy metabolism.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Superóxido Dismutase
/
Medicamentos de Ervas Chinesas
/
Traumatismo por Reperfusão
/
Isquemia Encefálica
/
Ratos Sprague-Dawley
/
Adenosina Trifosfatases
/
Glutationa Peroxidase
/
Malondialdeído
/
Metabolismo
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2006
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS