Effects of aminoguanidine on the lung injury induced by the total hepatic ischemia-reperfusion in rats / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 94-96, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-813758
ABSTRACT
OBJECTIVE@#To investigate the effects of aminoguanidine on the lung injury induced by the total hepatic ischemia-reperfusion in rats.@*METHODS@#The total hepatic ischemia-reperfusion model was built after blocking of the hepatic porta, suprahepatic and infrahepatic vena cava. Ninety Sprague-Dawley rats were assigned randomly into 3 groups Sham operation group (Group A, n=30); total hepatic ischemia group (Group B, n=30); and aminoguanidine treatment group (Group C, n=30). Each group was subdivided randomly into 3 subgroups (n=10) according to different time phases 20 minutes after the total hepatic vascular exclusion (T0), 4 hours after the reperfusion (T1), and 48 hours after the survival Group A and Group B were intravenously injected with normal saline ( mL/kg) while Group C was injected with aminoguanidine (20 mg/kg) dissolved in normal saline (1 mL/kg) 10 minutes before the open of the abdomin. The levels of portal blood nitric oxide ( O) endotoxin ( ET), tumor necrosis factor-alpha (TNF-alpha at T0 and T1 were detected; 48 hours survival rates and the lung wet/dry weight ratio were counted; and the histological changes of the lung tissues were observed.@*RESULTS@#Compared with Group A, the levels of portal vein NO, ET, and TNF-alpha T0 and T1 in Group B and Group C were significantly higher (P < 0.05 or P < 0.01). But those indexes of Group C were lower than those of Group B (P < 0.05). The 48-hour survival rate in Group C was higher than that in Group B (P < 0.05). The lung wet/dry weight ratio in Group C was lower than in Group B (P < 0.05) and the histological change of Group C was slighter than that in Group B.@*CONCLUSION@#Aminoguanidine has the protective effects on the lungs against the total hepatic ischemia-reperfusion induced injury.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Síndrome do Desconforto Respiratório
/
Traumatismo por Reperfusão
/
Distribuição Aleatória
/
Ratos Sprague-Dawley
/
Inibidores Enzimáticos
/
Óxido Nítrico Sintase Tipo II
/
Guanidinas
/
Fígado
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2006
Tipo de documento:
Artigo
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