Measurement of activated clotting time during cardiopulmonary bypass in infective endocarditis patients / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To investigate the proper dosage of heparin and protamin in treating the patients with infective endocarditis (IE) during the operation.@*METHODS@#Activated clotting time (ACT) was measured during and after cardiopulmonary bypass (CPB) in 30 patients with IE and 30 patients with rheumatic heart disease (RHD) respectively.@*RESULTS@#The dosage of heparin before bypass in IE group was significantly higher than that of RHD group (P0.05).@*CONCLUSION@#The dosage of protamin should be increased to 3 mg/kg as the heparin is over 400 U/kg before CPB in the patient with IE, but the ratio of protamin and heparin will not be obviously changed.