Construction of 2-dimensional tumor microvascular architecture phenotype in non-small cell lung cancer / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 712-717, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-814010
ABSTRACT
OBJECTIVE@#To construct a technological platform of 2-dimensional tumor microvascular architecture phenotype (2D-TAMP) expression.@*METHODS@#Thirty samples of non-small cell lung cancer (NSCLC) were collected after surgery. The corresponding sections of tumor tissue specimens to the slice of CT perfusion imaging were selected. Immunohistochemical staining,Gomori methenamine silver stain, and electron microscope observation were performed to build a technological platform of 2D-TMAP expression by detecting the morphology and the integrity of basement membrane of microvasculature, microvascular density, various microvascular subtype, the degree of the maturity and lumenization of microvasculature, and the characteristics of immunogenetics of microvasculature.@*RESULTS@#The technological platform of 2D-TMAP expression was constructed successfully. There was heterogeneity in 2D-TMAP expression of non-small cell lung cancer. The microvascular of NSCLC had certain characteristics.@*CONCLUSION@#2D-TMAP is a key technology that can be used to observe the overall state of micro-environment in tumor growth.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Fenótipo
/
Fisiologia
/
Fluxo Sanguíneo Regional
/
Capilares
/
Carcinoma Pulmonar de Células não Pequenas
/
Neoplasias Pulmonares
/
Neovascularização Patológica
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2008
Tipo de documento:
Artigo
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