Cognitive function, serum BDNF levels and BDNF gene Val66Met polymorphism in amnestic mild cognitive impairment / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 321-325, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-814076
ABSTRACT
OBJECTIVE@#To investigate the relationship between serum brain-derived neurotrophic factor, concentrations and BDNF gene Val66Met polymorphism and amnestic mild cognitive impairment (aMCI), and neuropsychological characteristics.@*METHODS@#Ninety-nine aMCI patients and 99 matched normal controls were recruited for the study. Multi-dimension neuropsychologic tests were used to extensively assess the cognitive function, an enzyme-linked immunosorbent assay was applied to measure serum BDNF concentrations, and polymerase chain reaction-restriction fragment length polymorphism was used to analyse BDNF gene Val66Met polymorphism in the subjects.@*RESULTS@#The scores of neuropsychologic tests in aMCI patients were significantly lower than those in the normal controls (all P0.05).@*CONCLUSION@#aMCI is characterized by episodic memory impairment. Decreased BDNF concentrations may play a role in the pathophysiology of aMCI, and BDNF gene Val66Met polymorphism may not be an important genetic factor in susceptibility to aMCI.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Valina
/
Sangue
/
Transtornos Cognitivos
/
Fator Neurotrófico Derivado do Encéfalo
/
Doença de Alzheimer
/
Genética
/
Amnésia
/
Metionina
Limite:
Idoso
/
Aged80
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2008
Tipo de documento:
Artigo
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