Experimental study of portal hemodynamics after microcapsule transplantation by intraportal and transarterial approach / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To compare the changes of portal hemodynamics after microcapsule transplantation by intraportal and transarterial approach with color doppler sonography.@*METHODS@#Thirty male dogs were divided into 2 groups randomly Group PV (microcapsules implanted into the portal vein) and Group HA (microcapsules implanted into the hepatic artery). Both groups were divided into 3 subgroups(PV1, PV2, and PV3; HA1, HA2, and HA3) according to the number of implanted microcapsules (8,000/kg, 16,000/kg, and 32,000/kg). The internal diameter and flow velocity of the portal vein were measured with color doppler sonography before the transplantation,within 24 hours and 1, 2, and 4 weeks after microcapsule transplantation.@*RESULTS@#The flow velocity of the portal vein in Group PV1 and PV2 within 24 hours increased significantly (P 0.05). The flow velocity of the portal vein in Group PV3 within 24 hours decreased significantly (P 0.05). The level of ALT in Group PV and Group HA all increased significantly (P<0.05). And when the numbers of microcapsule transplantation were same, the level of ALT in subgroup PV were significantly higher than that in subgroup HA (P<0.05).@*CONCLUSION@#Microcapsule transplantation by transarterial approach is safer than by intraportal way, and the hepatic artery can contain more microcapsule than the portal vein.