TGF-beta1-800G>A polymorphism and cerebral infarction in Chinese Han population / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To investigate the association between transforming growth factor beta1(TGF-beta1)-800G>A polymorphism and cerebral infarction (CI).@*METHODS@#The genotypes of 247 patients with atherosclerotic cerebral infarction and 167 sex- and age-matched healthy controls were detected by PCR-RFLP, and the frequency distribution of alleles calculated.@*RESULTS@#TGF-beta1-800G>A polymorphism was found in Han population in Hunan Province, China. The distribution of -800G>A genotypes was consistent with Hardy-Weinberg balance in the CI and healthy control group. There was no significant difference between genotypes and allele frequency of TGF-beta1-800G>A in the CI and control group (P>0.05). Logistic regression analysis suggested that no genotypes could increase or reduce the risk of CI onset (P>0.05).@*CONCLUSION@#TGF-beta1-800G>A polymorphism is not associated with CI in Han population in Hunan Province.